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InvestmentsAstraZeneca antibody cocktail succeeds in late-stage study to treat COVID-19 By Reuters

AstraZeneca antibody cocktail succeeds in late-stage study to treat COVID-19 By Reuters

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© Reuters. FILE PHOTO: The brand for AstraZeneca is seen exterior its North America headquarters in Wilmington, Delaware, U.S., March 22, 2021. REUTERS/Rachel Wisniewski

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By Yadarisa Shabong and Sachin Ravikumar

(Reuters) -AstraZeneca’s experimental COVID-19 drug has helped lower the danger of extreme illness or demise in a late-stage study, the British drugmaker mentioned on Monday, a lift to its efforts to develop coronavirus medicines past vaccines.

The drug, a cocktail of two antibodies referred to as AZD7442, decreased the danger of extreme COVID-19 or demise by 50% in non-hospitalised sufferers who’ve had signs for seven days or much less, assembly the primary objective of the study.

AstraZeneca (NASDAQ:)’s remedy, delivered by way of injection, is the primary of its form to present promise each as a preventative medication and as a therapy for COVID-19 following a number of trials. It is designed to shield individuals who shouldn’t have a powerful sufficient immune response to vaccines.

“These positive results show that a convenient intramuscular dose of AZD7442 could play an important role in helping combat this devastating pandemic,” Hugh Montgomery, the trial’s principal investigator, mentioned in an announcement.

Similar therapies made with a category of medicine referred to as monoclonal antibodies are being developed by Regeneron (NASDAQ:), Eli Lilly (NYSE:) and GlaxoSmithKline (NYSE:) with accomplice Vir. These therapies are accredited for emergency use in the United States for treating mild-to-moderate COVID-19.

AstraZeneca, whose COVID-19 vaccine has been broadly used globally, requested U.S. regulators final week to grant emergency use authorisation for AZD7442 as a preventative remedy.

AstraZeneca is submitting knowledge from varied AZD7442 research to world well being regulators, a spokeswoman mentioned on Monday.

“We’ll be continuing discussions with regulators around this new data,” she mentioned of Monday’s trial outcomes.

The trial occurred throughout 13 nations and concerned greater than 900 grownup individuals, with one half receiving AZD7442 and the remainder a placebo. Full trial outcomes will likely be submitted for publication in a peer-reviewed journal, AstraZeneca mentioned.

AZD7442 accommodates laboratory-made antibodies designed to linger in the physique for months to include the virus in case of an an infection. A vaccine, in distinction, depends on an intact immune system to develop focused antibodies and infection-fighting cells.

“An early intervention with our antibody can give a significant reduction in progression to severe disease, with continued protection for more than six months,” mentioned Mene Pangalos, govt vice chairman at AstraZeneca.

While Monday’s outcomes cowl the usage of AZD7442 in non-hospitalised sufferers, a separate trial can be learning its use as a therapy for hospitalised COVID-19 sufferers.

Other antibody cocktail therapies for COVID-19 have proven diversified levels of success.

Regeneron’s remedy confirmed 72% safety in opposition to symptomatic an infection in the primary week, and 93% after that. GSK-Vir’s confirmed a 79% discount in the danger of hospitalisation or demise due to any trigger, whereas Lilly’s remedy confirmed a 70% discount in viral load at day seven in contrast to a placebo.

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